Deficiência na Globulina de Ligação de Tiroxina: uma Revisão de Literatura

Autores

  • Kledson Lopes Barbosa Universidade Federal de Alagoas, Programa de Pós-Graduação Stricto Sensu em Química e Biotecnologia. AL, Brasil
  • Christiani Lozany Ferreira de Lima Araújo Centro Universitário Maurício de Nassau. SE, Brasil

DOI:

https://doi.org/10.17921/1415-6938.2018v22n2p104-111

Resumo

O hipotireoidismo congênito é classificado como a falta de hormônios tireoidianos após o nascimento, e que quando não tratado inicialmente,
contribui para o atraso acentuado do desenvolvimento e retardo mental. A ingestão adequada de iodo é necessária para a produção de hormônios tireoidianos. Visto que sua deficiência pode levar ao hipotireoidismo congênito em neonato, uma condição caracterizada, geralmente, por deficiência intelectual e nanismo, podendo ainda afetar a audição. O presente estudo teve como objetivo realizar uma revisão de literatura acerca da Hipotebegenemia e seus agravos relacionados à saúde. Hipotebegenemia doença genética, ligada ao cromossomo X e que acomete, principalmente, meninos. Ocorre por uma deficiência na proteína transportadora dos hormônios tireodianos - TBG. Para isto, realizaram-se buscas bibliográficas em bases eletrônicas, tais como: Bireme, Lilacs, SciELO, Pubmed e Periódicos Capes. Conclui-se que o hipotireoidismo subclínico na infância parece ser reversível na maioria dos casos. Contudo, os riscos de progressão desta condição não devem ser afastados, uma vez que as manifestações clínicas irão depender de determinadas condições, tal como as formas autoimunes.

Palavras chaves: Hipotireoidismo. Tireoglobulina Ligadora. Doença Genética.


Abstract

Congenital hypothyroidism is classified as the lack of thyroid hormones after birth, and when not treated initially, it contributes to marked
developmental delay and mental retardation. The ingestion of iodide it is necessary for the thyroid hormones production. Its deficiency can lead
to congenital hypothyroidism in the neonate, a condition usually characterized by intellectual deficiency and dwarfism, and may even affect hearing. The objective of the present study was to carry out a review of the literature on Hypothembemia and its health related diseases. It is a Hipotebegenemia genetic disease, linked to the X chromosome and affects mainly boys. It occurs due to a deficiency in thyroid hormone carrier protein - TBG. For this, bibliographic searches were carried out in electronic databases, such as: Bireme, Lilacs, SciELO, Pubmed and Periodicals CAPES. It is concluded that subclinical hypothyroidism in childhood seems to be reversible in most cases. However, the risks of progress by category are not required, since that the clinical manifestations will depend on conditions, such as autoimmune forms.

Keywords: Hypothyroidism. Binding Thyroglobulin. Genetic Disease.

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2018-07-30

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BARBOSA, K. L.; ARAÚJO, C. L. F. de L. Deficiência na Globulina de Ligação de Tiroxina: uma Revisão de Literatura. Ensaios e Ciência C Biológicas Agrárias e da Saúde, [S. l.], v. 22, n. 2, p. 104–111, 2018. DOI: 10.17921/1415-6938.2018v22n2p104-111. Disponível em: https://ensaioseciencia.pgsscogna.com.br/ensaioeciencia/article/view/5449. Acesso em: 29 mar. 2024.

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